Key Points: Rejuran (polynucleotide) skin booster treatments can cause inflammation, post-injection bumps (embossing), and discomfort — but these side effects are closely linked to how the product is delivered into the skin. At Onu Clinic near Sinnonhyeon, a needle-free injection device is used to disperse Rejuran evenly into the dermis, significantly reducing downtime, embossing, and the risk of inflammatory reactions.
Why Does Rejuran Cause Inflammation and Pain After Treatment?
Rejuran's active ingredient, polynucleotide (PN), naturally triggers a mild biological response as it stimulates cell proliferation — this is an expected part of the skin regeneration process.
However, when physical needle trauma combines with uneven product distribution or localized clumping beneath the skin, the resulting pressure can escalate into excessive heat, swelling, or an inflammatory reaction.
In cases where treatment is performed under suboptimal skin conditions or with high injection pressure, the immune system may interpret the stimulus as a threat and mount a delayed inflammatory response.
The key to minimizing Rejuran-related inflammation is reducing mechanical skin trauma while ensuring the product is dispersed as evenly as possible throughout the dermal layer.
What Causes Post-Treatment Embossing and How Can It Be Avoided?
Embossing — the raised, bumpy texture that can persist for several days after Rejuran injections — is one of the most common concerns among patients, particularly those returning to work or social commitments shortly after treatment.
Traditional needle-based delivery concentrates product at discrete injection points, which can create visible bumps and tracking marks that take time to absorb.
At Onu Clinic, a needle-free injection device is used instead. This system uses high-pressure energy to break Rejuran into fine particles that penetrate directly into the dermis without creating puncture wounds.
Because no needle marks are left, residual redness typically resolves within approximately two hours, and product distribution across the dermal layer is more uniform — reducing the localized clumping that leads to embossing and nodule formation.
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How Does Needle-Free Delivery Reduce Pain and Improve Rejuran Outcomes?
Eliminating the needle also substantially reduces procedural discomfort. The fine-particle dispersion method allows the product to reach the dermis with less force applied to surrounding tissue.
Because the product is dispersed evenly rather than deposited at single points, there is less risk of localized pressure, nodule formation, or the delayed inflammatory reactions associated with product pooling.
Uniform dermal distribution also means the regenerative ingredients in Rejuran are delivered without loss, supporting consistent skin regeneration across the treated area.
What Is the Clinical Approach to Rejuran at Onu Clinic?
Dr. Heejin Park currently serves as a clinical advisor for PHARMARESEARCH, the manufacturer of Rejuran, and applies that research-level understanding of safe and effective product delivery directly in the treatment room.
Rather than following a one-size-fits-all protocol, Onu Clinic designs individualized treatment plans that account for each patient's skin condition, sensitivity, and scheduling constraints — including anticipated downtime.
The clinical priority is a safe, honest approach: no unnecessary treatments, and a focus on helping patients return to daily life as quickly as possible after each session.
Frequently Asked Questions
Is inflammation after Rejuran treatment normal?
A mild inflammatory response is a normal part of the skin regeneration process triggered by Rejuran's polynucleotide (PN) ingredient. However, excessive swelling, prolonged redness, or nodule formation may indicate uneven product distribution or physical trauma from the injection method.
How long does Rejuran embossing last after a standard injection?
With conventional needle-based Rejuran delivery, raised bumps or embossing at injection sites can persist for several days. With a needle-free delivery method, visible redness may resolve within approximately two hours, and embossing is significantly reduced due to more even product distribution.
Can a needle-free device deliver Rejuran as effectively as a traditional syringe?
Needle-free delivery systems use high-pressure energy to disperse Rejuran into fine particles that penetrate the dermis directly. This approach can distribute the product uniformly across the treatment area without loss, supporting consistent skin regeneration results.
Who is most at risk for Rejuran side effects such as inflammation?
Patients with compromised skin conditions at the time of treatment, or those who receive high-pressure injections with uneven product delivery, may be more susceptible to delayed inflammatory reactions. A careful pre-treatment skin assessment and appropriate injection technique help reduce this risk.
How soon can I return to daily activities after a Rejuran treatment at Onu Clinic?
With the needle-free delivery approach used at Onu Clinic, most patients find they can resume normal activities shortly after treatment, as visible redness typically fades within a few hours and there is no significant embossing or needle marking.